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KMID : 1059520110550020256
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Journal of the Korean Chemical Society
2011 Volume.55 No. 2 p.256 ~ p.261
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Novel Synthesis of bis Acetylated Hybrid Pyrazoles as Potent Anticandidiasis Agents
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Kanagarajan, V.
Ezhilarasi, M. R.
Gopalakrishnan, M.
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Abstract
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A new series of bis acetylated hybrid pyrazoles were synthesized and characterized by their melting point, elemental analysis, MS, FT-IR, one-dimensional , and NMR spectroscopic data. All the synthesized compounds were tested for their in vitro antifungal activities against Candida sp. namely Candida albicans, Candida glabrata, Candida parapsilosis, Candida dubliniensis and Candida tropicalis. A close inspection of the in vitro anticandidal activity profile in differently electron donating ( and ) and electron withdrawing (-F, -Cl, and Br) functional group substituted phenyl rings of novel hybrid pyrazoles exerted strong anticandidal activity against all the tested Candida species.
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KEYWORD
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Bis acetylated hybrid pyrazoles, In situ acetylation, Spectral analysis, Candida sp., Anticandidal activity
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